Elsevier

Immunology Letters

Volume 149, Issues 1–2, January 2013, Pages 119-122
Immunology Letters

Immunodominance of HLA-B27-restricted HIV KK10-specific CD8+ T-cells is not related to naïve precursor frequency

https://doi.org/10.1016/j.imlet.2012.10.002Get rights and content

Abstract

The factors that determine the immunodominance, efficacy and almost ubiquitous presence of CD8+ T-cell responses to the HLA-B27-restricted HIV-1 p24 Gag-derived KK10 epitope remain to be fully elucidated. Here, we show that neither the precursor frequency nor the priming capacity of KK10-reactive CD8+ T-cells within the naïve pool differ substantially in comparison to other specificities. These data implicate alternative mechanisms in the relative protection conferred by CD8+ T-cell responses to this epitope.

Highlights

► The precursor frequency of HIV reactive CD8+ T-cells restricted by HLA-B*2705 is low. ► The in vitro priming capacity of these cells appears also ordinary. ► The precursor frequency cannot explain the protective nature of this response per se.

Section snippets

Conflict of interest statement

The authors declare that they have no competing financial interests.

Acknowledgements

This work was supported by Sidaction, the French Agence Nationale de la Recherche sur le SIDA (ANRS), the ANR (project ANR-09-JCJC-0114-01) and the JDRF (grant 1-2008-106).

We are grateful to Matthew Albert and Cécile Alanio for discussion on the enumeration of antigen-specific naïve CD8+ T-cells and to the personnel of ICAReB platform for recruitment and sampling of healthy volunteers.

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    1

    These authors contributed equally to this work.

    2

    Current address: Centro de Investigacion en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.

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