Immunodominance of HLA-B27-restricted HIV KK10-specific CD8+ T-cells is not related to naïve precursor frequency
Highlights
► The precursor frequency of HIV reactive CD8+ T-cells restricted by HLA-B*2705 is low. ► The in vitro priming capacity of these cells appears also ordinary. ► The precursor frequency cannot explain the protective nature of this response per se.
Section snippets
Conflict of interest statement
The authors declare that they have no competing financial interests.
Acknowledgements
This work was supported by Sidaction, the French Agence Nationale de la Recherche sur le SIDA (ANRS), the ANR (project ANR-09-JCJC-0114-01) and the JDRF (grant 1-2008-106).
We are grateful to Matthew Albert and Cécile Alanio for discussion on the enumeration of antigen-specific naïve CD8+ T-cells and to the personnel of ICAReB platform for recruitment and sampling of healthy volunteers.
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These authors contributed equally to this work.
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Current address: Centro de Investigacion en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.