Elsevier

Immunology Letters

Volume 148, Issue 1, November–December 2012, Pages 39-40
Immunology Letters

Letter to the Editor
Do defective B cells contribute to reduced Treg cells and autoimmunity in patients with Common Variable Immunodeficiency?

https://doi.org/10.1016/j.imlet.2012.07.005Get rights and content

Highlights

► A recent report highlights the Treg requirement for competent regulatory B cells. ► Common Variable Immunodeficiency patients provide a good model to test this hypothesis. ► CVID patients with autoimmunity have reduced Treg cells and switched memory B cells. ► They also have expanded populations of immature B cells (CD19+ CD24hi, CD38hi, CD5+). ► This supports the hypothesis that competent B cells contribute to Treg responses.

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Cited by (2)

  • Common variable immunodeficiency and autoimmunity - an inconvenient truth

    2014, Autoimmunity Reviews
    Citation Excerpt :

    It has been postulated that the reduced number of Treg cells may be driven by a defect in B cell homeostasis, in which an elevated number of regulatory B cells expressing CD19+CD24hiCD38hi were found in CVID patients with autoimmunity, reflected an expanded regulatory B cell pool with reduced IL-10 production. In addition, the numbers of switched memory B cells, CD19+CD27+IgD− were reduced in the group with autoimmunity, though not exclusively [59]. Impaired differentiation, maturation, and function of dendritic cells was also reported to be involved in the pathology of CVID and autoimmunity [60].

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