Prevalence of herpes -, measles morbillivirus-, parvovirus B19 - and rubella viruses immunoglobulin G among women with chronic hepatitis B of reproductive age in Denmark: A cross-sectional study

https://doi.org/10.1016/j.ijid.2020.09.1477Get rights and content
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Highlights

  • IgG against vertically transmitted viruses generally high among women with chronic hepatitis B.

  • Seroprevalence differed among women with respect to region of origin.

  • Generally small differences in seroprevalence compared to background population.

  • Women with chronic hepatitis B can follow general antenatal care in Denmark.

Abstract

Objectives

The aim of this study was to investigate whether the seroprevalence of IgG antibodies against seven viruses (cytomegalovirus, herpes simplex virus 1&2, measles morbillivirus, parvovirus B19, rubella, and varicella-zoster virus), which can potentially compromise maternal and fetal wellbeing, differs based on country of origin among women with chronic hepatitis B (CHB).

Method

This study was a single-center, hospital-based cross-sectional study. The study included women with CHB 15–45 years of age, included in the Danish Database for Hepatitis B and C. Seroprevalence estimates were calculated with a 95% confidence interval and were compared between age groups, regions of origin, and to the general population.

Results

177 women were included in the study. Overall, the seroprevalences of antibodies were similar among women with CHB with origin outside Denmark and compared to the general population in Denmark, but there was a notable difference in the seroprevalence of antibodies against herpes simplex 2 between women from Africa (37.1% CI 95% 22.0;55.1) and women from the Middle East (2.5% CI 95% 0.1;14.7).

Conclusion

Women with CHB whose origin is outside Denmark do not appear to differ, based on origin, or be at greater risk of acquiring these viruses during pregnancy than their Danish counterparts.

Abbreviations

CMV
Cytomegalovirus
CHB
chronic hepatitis B
CRS
Congenital Rubella Syndrome
CSV
Congenital Varicella Syndrome
DANHEP
Danish Database for Hepatitis B and C
HBV
Hepatitis B virus
HSV1
Herpes Simplex virus 1
HSV2
Herpes Simplex virus 2
MMR
Measles, mumps, and rubella
VZV
Varicella-zoster virus
Morbillivirus
Measles morbillivirus

Keywords

Seroprevalence
Chronic hepatitis B
Herpes viruses
Morbillivirus
Parvovirus B19 rubella
Pregnancy

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