Case Report
Cerebral Rhizomucor Infection Treated by Posaconazole Delayed-Release Tablets in an Allogeneic Stem Cell Transplant Recipient

https://doi.org/10.1016/j.ijid.2016.12.014Get rights and content
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Highlights

  • Mucormycosis (zygomycosis) is an emerging fungal disease in allogeneic hematopoietic stem cell transplant recipients.

  • Higher posaconazole plasma concentration might be obtained with posaconazole delayed-release tablets.

Summary

Mucormycosis (zygomycosis) is an emerging fungal disease in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. A 30-year-old woman diagnosed with acute myelomonocytic leukemia and needing allo-HSCT presented pulmonary and cerebral infection due to Rhizomucor pusillus. This fungal infection was treated with surgical treatment and posaconazole delayed-release tablets. This strategy allowed reaching high drug levels that could not be obtained with the posaconazole solution.

Keywords

Posaconazole delayed-release tablets
Rhizomucor pusillus
Zygomycosis
Mucormycosis

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