Letter to the EditorDissemination of multidrug-resistant Klebsiella pneumoniae clinical isolates with various combinations of carbapenemases (NDM-1 and OXA-72) and 16S rRNA methylases (ArmA, RmtC and RmtF) in Nepal
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Cited by (38)
Aminoglycoside Resistance: Updates with a Focus on Acquired 16S Ribosomal RNA Methyltransferases
2020, Infectious Disease Clinics of North AmericaCitation Excerpt :RmtF is the most prevalent MTase, after ArmA/RmtB/RmtC. The first identification of RmtF was in K pneumoniae isolates in La Réunion Island in 2011,46 followed by Enterobacterales from India,47–49 United Kingdom,47,50 Nepal,51 South Africa,52 United States,53 Australia,54 Egypt,55 Switzerland,56 and Ireland,50 and P aeruginosa from Nepal.57 One of the clinical risks associated with RmtF producers is that they frequently coproduce NDM-group metallo-β-lactamase, which confers carbapenem resistance.
The spectrum of bacteria and mechanisms of resistance identified from the casualties treated in the Israeli field hospital after the earthquake in Nepal, 2015: A retrospective analysis
2020, Travel Medicine and Infectious DiseaseCitation Excerpt :Further molecular study was not done and the exact mechanisms of resistance were not studied [33]. In a non-prevalence based study from Nepal NDM-1, OXA-72 and 16S rRNA methylases were described [34]. In the only community acquired report, ESBL production was noted in 35.9% of clinical Gram negative bacteria isolated from outpatients.
Aminoglycoside Resistance: The Emergence of Acquired 16S Ribosomal RNA Methyltransferases
2016, Infectious Disease Clinics of North AmericaCitation Excerpt :In a survey at a hospital in India, 3.7% of Enterobacteriaceae isolates had rmtC, often along with blaNDM.47 rmtC has also been found among K pneumoniae clinical isolates in Nepal.48 These data suggest that rmtC likely originated in the Indian subcontinent and rmtC is being incorporated by MDR/XDR Enterobacteriaceae, in particular those producing NDM-type carbapenemase.
Development and evaluation of immunochromatography to detect Gram-negative bacteria producing ArmA 16S rRNA methylase responsible for aminoglycoside resistance
2015, Journal of Microbiological MethodsCitation Excerpt :After 15 min, the strips were visually inspected, with a colored line at position b defined as a positive reaction. The immunochromatographic assay was evaluated using 101 clinical isolates of A. baumannii, E. coli, Enterobacter cloacae, Enterobacter hormaechei, Klebsiella pneumoniae, Klebsiella variicola and P. aeruginosa (Table 3), which harbor the methylase genes armA, rmtA, rmtB, rmtC, rmtF, armA + rmtB, armA + rmtC and rmtC + rmtF, respectively (Tada et al., 2013a,2013b). All the isolates, except for the 16S rRNA methylase-negative control strain (K. pneumoniae), were resistant to aminoglycoside (MIC ≥ 128 μg/mL) (Table 4).
Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates in a university hospital in Nepal reveals the emergence of a novel epidemic clonal lineage
2015, International Journal of Antimicrobial Agents