Original pre-clinical scienceSingle-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization
Section snippets
Subjects
The study population was a cohort of consecutive organ donors managed by the California Transplant Donor Network (CTDN, Oakland, CA) from 2001 to 2005. Treating physicians at hospitals throughout the region identified potential brain-dead organ donors and consent for organ donation and collection of biologic materials was obtained from family members or next of kin. CTDN staff subsequently assumed management of the organ donors, and management was conducted according to protocols developed by
Subjects
A total of 951 organ donors, of a total of 1,223 managed by the CTDN from 2001 to 2005, had stored DNA available for analysis and defined the study cohort. The clinical characteristics of the cohort are shown in Table 1.
Association of clinical characteristics with lung utilization
From a total of 951 potential donors, lung allografts were used from 325 individuals, yielding an overall lung utilization rate of 34%. Both lungs were transplanted together from 216 (23%), both single lungs were transplanted from 47 (5%), only 1 single lung was transplanted
Discussion
In this study of 951 potential organ donors, we found that the GG genotype of the Ser49Gly SNP in the β1-adrenergic receptor gene and the GG genotype of the Gly16Arg SNP in the β2-adrenergic receptor gene are independently associated with increased lung allograft utilization from eligible donors. We also found that the combination of 3 favorable (associated with higher utilization) genotypes at 3 SNPs—the Ser49Gly SNP and Arg 389Gly SNPs, both in the β1-adrenergic receptor gene, and the
Disclosure statement
This work was initially presented as Abstract 551 (Session 38) at the 29th annual meeting of the International Society for Heart and Lung Transplantation, April 2009, Paris, France.
The study was supported by Research Grants NHLBI K23 HL085526 (to A.S.), NICHD HD047349 (to A.S.) and NHLBI HL51856 (M.A.M.).
The authors have no conflicts of interest to disclose.
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