Original articleClinical endoscopyA retrospective study on the safety, diagnostic yield, and therapeutic effects of endoscopic unroofing for small gastric subepithelial tumors
Section snippets
Materials and methods
This retrospective study of prospectively collected clinical data was conducted at the Division of Gastroenterology and Hepatology, Department of Internal Medicine III of the Medical University of Vienna, a tertiary academic referral center for Vienna and eastern Austria. The study protocol was approved by the internal review board of the Medical University of Vienna (EK 1707/2015) and registered at clinicaltrials.gov (NCT02587923). Patients who underwent endoscopic unroofing of gastric SETs
Results
Within the study period, a total of 14 patients (7 men; 7 women; median age, 70 years; range, 51-95 years) underwent endoscopic unroofing of 14 gastric SETs. The mean diameter of the subepithelial lesions was 26 ± 13 mm at endosonography (range of maximum diameters. 10-60 mm). Most lesions had arisen from the muscularis propria layer. In most cases (9/14), endoscopic unroofing was done exclusively for diagnostic purposes (including 3 patients who had already undergone EUS-FNA with a
Discussion
This is the first study to systematically investigate endoscopic unroofing for gastric SETs with regard to safety, diagnostic yield, and therapeutic effect over time. The technique proved to be feasible in almost all cases and showed a very favorable safety profile. The diagnostic yield was excellent because the specimens were big enough for a detailed histopathologic assessment, including mitotic analysis and immunohistochemistry. The most surprising result came from follow-up examinations:
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DISCLOSURE: All authors disclosed no financial relationships relevant to this publication.
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