Research briefPlasmodium vivax: allele variants of the mdr1 gene do not associate with chloroquine resistance among isolates from Brazil, Papua, and monkey-adapted strains
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Acknowledgments
We are grateful to Prof. Luiz H. Pereira da Silva (CEPEM, Centro de Pesquisas em Medicina Tropical, Rondonia, Brazil) for facilities and to Drs. William E. Collins (Centers for Disease Control and Prevention, Chamblee, GA, USA) and Juan M. Villalobos (CEPEM, Centro de Pesquisas em Medicina Tropical, Rondonia, Brazil) for P. vivax isolates. To Drs. Jianbing Mu, Emilio Fernando Merino and Alan Durham for help with in silico analysis. To Mr. Cassiano Pereira Nunes for the drawing in Fig. 2, to Ms.
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The molecular basis of antimalarial drug resistance in Plasmodium vivax
2021, International Journal for Parasitology: Drugs and Drug ResistanceCitation Excerpt :Sequencing of pvmdr1 across several regions of the world has revealed more than fifty polymorphisms in this gene, as well as copy number variants (CNVs). These single nucleotide polymorphisms (SNPs) correspond to amino acid changes throughout the protein sequence, including in the ATP binding domains and multiple transmembrane regions (Sá et al., 2005) (Fig. 2A). No single SNP, or set of SNPs, have emerged as definitive drug resistance markers.
Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions
2021, International Journal for Parasitology: Drugs and Drug ResistanceCitation Excerpt :Taken together, these findings point to different mechanisms of CQ resistance in these two species. The gene coding for the P. vivax ortholog of pfmdr-1, a secondary CQ resistance factor in P. falciparum, was characterized in 2005 (Brega et al., 2005; Sá et al., 2005). It encodes a protein with 12 transmembrane domains and 1464 amino acids, with an apparent molecular mass of 165 kDa (Fig. 6).
Quantitative characterization of hemozoin in Plasmodium berghei and vivax
2017, International Journal for Parasitology: Drugs and Drug ResistanceCitation Excerpt :However, a different human study found increases in pvmdr copy number were associated with resistance to mefloquine yet actually enhanced susceptibility to chloroquine (Vargas-Rodriguez Rdel et al., 2012). Transcriptional upregulation of wild type pvcg10 (pvcrt-o) transfected into CS P. falciparum facilitates reduced chloroquine susceptibility, if not full resistance, but no direct role for transporters in CR P. vivax parasites has been established (Sá et al., 2005). Plasmodium berghei infects rodents and is considered a useful model for studying P. vivax infection and alternative forms of chloroquine resistance (Espinosa et al., 2013).
Polymorphism analysis of multidrug resistance protein 1 gene in imported Plasmodium vivax in Yunnan Province
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