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Sleep quality and emotional reactivity cluster in bipolar disorders and impact on functioning

Published online by Cambridge University Press:  23 March 2020

B. Etain ,
O. Godin ,
C. Boudebesse ,
V. Aubin ,
J.M. Azorin ,
F. Bellivier ,
T. Bougerol ,
P. Courtet ,
S. Gard  and
J.P. Kahn
...Show all authors
B. Etain*
Affiliation:
AP–HP, GH Saint-Louis–Lariboisière–Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, Pôle Neurosciences Tête et Cou, Paris, France Université Paris Diderot, Inserm UMRS 1144, Paris, France Fondation FondaMental, Créteil, France
O. Godin
Affiliation:
Fondation FondaMental, Créteil, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1136, Institut Pierre-Louis d’Épidémiologie et de Santé Publique, Inserm 75013, Paris, France
C. Boudebesse
Affiliation:
Fondation FondaMental, Créteil, France Université Paris-Est, UPEC, Inserm, U955, Équipe Psychiatrie Translationelle, AP–HP, Hôpitaux Universitaires Henri-Mondor, DHU PePsy, Pôle de Psychiatrie, 94000Créteil, France
V. Aubin
Affiliation:
Université Paris Diderot, Inserm UMRS 1144, Paris, France Service de psychiatrie, Centre hospitalier Princesse-Grace, Avenue PasteurMonaco
J.M. Azorin
Affiliation:
Fondation FondaMental, Créteil, France Pôle de psychiatrie, Hôpital Sainte-Marguerite, Assistance Publique–Hôpitaux de Marseille, Marseille, France Aix-Marseille Université, CNRS, CRN2M UMR7286, 13344Marseille cedex15, France
F. Bellivier
Affiliation:
AP–HP, GH Saint-Louis–Lariboisière–Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, Pôle Neurosciences Tête et Cou, Paris, France Université Paris Diderot, Inserm UMRS 1144, Paris, France Fondation FondaMental, Créteil, France
T. Bougerol
Affiliation:
Fondation FondaMental, Créteil, France Clinique Universitaire de Psychiatrie, CHU de Grenoble, Grenoble, France
P. Courtet
Affiliation:
Fondation FondaMental, Créteil, France Département d’Urgence et Post-Urgence Psychiatrique, CHRU Montpellier, INSERM U1061, Université Montpellier 1, Montpellier, France
S. Gard
Affiliation:
Fondation FondaMental, Créteil, France Hôpital Charles-Perrens, Centre Expert Trouble Bipolaire, Service de psychiatrie adulte, Pôle 3-4-7, Bordeaux, France
J.P. Kahn
Affiliation:
Fondation FondaMental, Créteil, France Université de Lorraine, CHU de Nancy, Pôle 6 de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy1, rue du Docteur-Archambault, 54520Laxou cedex, France
C. Passerieux
Affiliation:
Fondation FondaMental, Créteil, France Université de Versailles Saint-Quentin, Centre Hospitalier de Versailles, Service de Psychiatrie Adulte, Le Chesnay, France
M. Leboyer
Affiliation:
Fondation FondaMental, Créteil, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1136, Institut Pierre-Louis d’Épidémiologie et de Santé Publique, Inserm 75013, Paris, France
C. Henry
Affiliation:
Fondation FondaMental, Créteil, France Sorbonne Universités, UPMC Université Paris 06, UMR_S 1136, Institut Pierre-Louis d’Épidémiologie et de Santé Publique, Inserm 75013, Paris, France
*
*Corresponding author. AP–HP, GH Saint-Louis–Lariboisière–Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, Pôle Neurosciences Tête et Cou, Paris, France. E-mail address:bruno.etain@inserm.fr (B. Etain).
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Abstract

Objective:

Bipolar disorders (BD) are characterized by sleep disturbances and emotional dysregulation both during acute episodes and remission periods. We hypothesized that sleep quality (SQ) and emotional reactivity (ER) defined clusters of patients with no or abnormal SQ and ER and we studied the association with functioning.

Method:

We performed a bi-dimensional cluster analysis using SQ and ER measures in a sample of 533 outpatients patients with BD (in remission or with subsyndromal mood symptoms). Clusters were compared for mood symptoms, sleep profile and functioning.

Results:

We identified three clusters of patients: C1 (normal ER and SQ, 54%), C2 (hypo-ER and low SQ, 22%) and C3 (hyper-ER and low SQ, 24%). C1 was characterized by minimal mood symptoms, better sleep profile and higher functioning than other clusters. Although highly different for ER, C2 and C3 had similar levels of subsyndromal mood symptoms as assessed using classical mood scales. When exploring sleep domains, C2 showed poor sleep efficiency and a trend for longer sleep latency as compared to C3. Interestingly, alterations in functioning were similar in C2 and C3, with no difference in any of the sub-domains.

Conclusion:

Abnormalities in ER and SQ delineated three clusters of patients with BD and significantly impacted on functioning.

Keywords

Bipolar disorderEmotional reactivitySleepCluster analysisFunctioning
Type
Original article
Information
European Psychiatry , Volume 45 , September 2017 , pp. 190 - 197
Copyright
Copyright © European Psychiatric Association 2017

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