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Deficit schizophrenia: An overview of clinical, biological and treatment aspects

Published online by Cambridge University Press:  16 April 2020

S. Galderisi  and
M. Maj
S. Galderisi*
Affiliation:
Department of Psychiatry, Medical School, University of Naples SUN, Largo Madonna delle Grazie, 80134Naples, Italy
M. Maj
Affiliation:
Department of Psychiatry, Medical School, University of Naples SUN, Largo Madonna delle Grazie, 80134Naples, Italy
*
*Corresponding author. Tel.: +39 0815 666 504; fax +39 0815 666 523. E-mail address:sgalderi@tin.it (M. Bernardo).
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Abstract

The concept of deficit schizophrenia is regarded as one of the most promising attempts to reduce heterogeneity within schizophrenia. This paper summarizes the clinical, neurocognitive, brain imaging and electrophysiological correlates of this subtype of schizophrenia. Attempts to identify genetic and non-genetic risk factors are reviewed. Methodological limitations of studies supporting the efficacy of atypical antipsychotics in the treatment of the syndrome are highlighted. Two decades of research on deficit schizophrenia have failed to prove that it represents the extreme end of a severity continuum in schizophrenia, while some findings support the claim that it may be a separate disease entity.

Keywords

Deficit SchizophreniaNondeficit schizophreniaHeterogeneitySchizophrenia subtypesMRIGenetic
Type
Review
Information
European Psychiatry , Volume 24 , Issue 8 , December 2009 , pp. 493 - 500
Copyright
Copyright © Elsevier Masson SAS 2009

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