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Distribution of 1298A > C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia

Published online by Cambridge University Press:  16 April 2020

Bartosz Kempisty ,
Anna Bober ,
Marta Łuczak ,
Piotr Czerski ,
Aleksandra Szczepankiewicz ,
Joanna Hauser  and
Paweł P. Jagodziński
Bartosz Kempisty
Affiliation:
Department of Biochemistry and Molecular Biology, University of Medical Sciences, 6 Swiecickiego St., 60-781Poznan, Poland
Anna Bober
Affiliation:
Department of Biochemistry and Molecular Biology, University of Medical Sciences, 6 Swiecickiego St., 60-781Poznan, Poland
Marta Łuczak
Affiliation:
Department of Biochemistry and Molecular Biology, University of Medical Sciences, 6 Swiecickiego St., 60-781Poznan, Poland
Piotr Czerski
Affiliation:
Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, 27/33 Szpitalna St. 60-572Poznan, Poland
Aleksandra Szczepankiewicz
Affiliation:
Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, 27/33 Szpitalna St. 60-572Poznan, Poland
Joanna Hauser
Affiliation:
Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, 27/33 Szpitalna St. 60-572Poznan, Poland
Paweł P. Jagodziński*
Affiliation:
Department of Biochemistry and Molecular Biology, University of Medical Sciences, 6 Swiecickiego St., 60-781Poznan, Poland
*
*Corresponding author. Tel.: +48 (061)8546 513; fax: +48 (061)8546 510. E-mail address: pjagodzi@am.poznan.pl (P.P. Jagodziński).
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Abstract

We investigated the genotype frequency of methylenetetrahydrofolate reductase (MTHFR) 1298A > C polymorphism in the group of patients with bipolar disorder type I (BDI) (n = 200) and schizophrenia (n = 200) and in the control group (n = 300). Odds ratio (OR) for patients with BD and schizophrenia in 1298CC homozygous state was 3.768 (95% CI = 1.752–8.104); P = 0.0003; (P = 0.0006 after Bonferroni correction) and 2.694; (95% CI = 1.207–6.013); P = 0.0123 (P = 0.0246 after Bonferroni correction), respectively. The stratification of patients based on gender revealed significant association of 1298CC genotype with female patients only with BDI (OR = 7.293; 95% CI = 2.017–26.363; P = 0.0005).

Our results confirm association of BD and schizophrenia with the 1p36.3 MTHFR locus and with the methyl group transfer using folate-dependent one-carbon pathway.

Keywords

Methylenetetrahydrofolate reductase (MTHFR)PolymorphismBipolar disorder I (BDI)Schizophrenia
Type
Genetic Epidemiology and Its Methods
Information
European Psychiatry , Volume 22 , Issue 1 , January 2007 , pp. 39 - 43
Copyright
Copyright © Elsevier Masson SAS 2007

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