Clinical investigationVentricular dyssynchronyRelationship Between Intraventricular Cardiac Asynchrony and Degree of Systolic Dysfunction
Section snippets
Patient Population
A total of 316 consecutive patients referred for echocardiographic Doppler study comprised the study group. All of them had a LV ejection fraction (LVEF) assessed by means of Simpson’s method (4- and 2-chamber volumes were averaged) of less than 40%. Exclusion criteria were: patients on CRT or paced, atrial fibrillation with rapid ventricular response, unwillingness of the patient to be enrolled, inaccurate determination of LVEF, bad acoustic window, and severe valvular heart disease. Patients
Results
Mean age of patients was 62.14 ± 13.5 years. A total of 220 (69.6%) were men. The proportion of men was similar in the 3 groups of patients and in the control group (18 [62.1%], 101 [75.9%], 87 [77.7%], and 32 [71.1%] in control, LVEF 31%-40%, LVEF 21%-30%, and LVEF <20% groups, respectively). Table 1 shows the baseline characteristics of the 3 groups.
There were significant differences between the New York Heart Association classes and the level of systolic dysfunction. Most patients with LVEF
Discussion
The results of this study enhance the usefulness of Doppler echocardiography in the assessment of mechanical cardiac asynchrony.14, 15 Our findings show that the prevalence of intraventricular cardiac asynchrony does not depend on the degree of LV systolic dysfunction. Furthermore, when the results are analyzed taking into account the origin of the systolic dysfunction, the findings reinforce the previous results: neither in the ischemic group nor in the nonischemic group is there any
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Cited by (5)
Heart failure patients selection for cardiac resynchronization therapy
2011, European Journal of Internal MedicineCitation Excerpt :20% to 30% of CHF patient with wide QRS duration may not have mechanical dyssynchrony [55]. A study of 316 patients with EF less than 40% found that the degree of LV systolic dysfunction was not related to the presence of cardiac dyssynchrony either in ischemic or non-ischemic cardiomyopathy, which suggested a specific echocardiographic Doppler study should always be performed to assess the existence of cardiac dyssynchrony in those who were candidates to resynchronization therapy [56]. Echocardiographic assessment of mechanical dyssynchrony may provide a better insight than prolongation of QRS alone [57,58].
Echocardiography and Cardiac resynchronization therapy. Room for hope?
2008, Revista Espanola de CardiologiaDyssynchrony contributes to false-positive myocardial perfusion SPECT results in patients with stable angina
2011, European Journal of Echocardiography