Research paperClassification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations
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Keywords
Liver cancer
Tumor microenvironment
Tumor-associated macrophage
Regulatory T cell
Abbreviations
TAM
tumor-associated macrophage
Treg
regulatory T cell
TME
tumor microenvironment
HCV
hepatitis C virus
HBV
hepatitis B virus
HCC
hepatocellular carcinoma
ICC
intrahepatic cholangiocarcinoma
cHCC-ICC
combined hepatocellular carcinoma-intrahepatic cholangiocarcinoma
WGS
whole genome sequencing
ICGC
International Cancer Genome Consortium
FPKM-UQ
fragments per kilobase of exon per million fragments mapped with upper quartile normalization
CYT
cytolytic activity
CNA
copy number alternation
PCAWG
Pan-Cancer Analysis of Whole Genomes
HR
hazard ratio
CI
confidence interval
OR
odds ratio
GSEA
gene set enrichment analysis
ECM
extracellular matrix
FDR
false discovery rate
SNV
single nucleotide variant
INDEL
insertion and deletion
TCGA
The Cancer Genome Atlas
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© 2020 The Authors. Published by Elsevier B.V.