Sprouty4 correlates with favorable prognosis in perihilar cholangiocarcinoma by blocking the FGFR-ERK signaling pathway and arresting the cell cycle
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Keywords
Sprouty 4
Perihilar cholangiocarcinoma
Prognosis
Proliferation
Cell cycle
Abbreviations
CCA
cholangiocarcinoma
PHCC
perihilar cholangiocarcinoma
ICC
intrahepatic cholangiocarcinoma
DCC
distal cholangiocarcinoma
AJCC/UICC
American Joint Committee on Cancer/Union for International Cancer Control
SPRY
sprouty
IDH
isocitrate dehydrogenase
TMA
tissue microarray
OS
overall survival
FBS
fetal bovine serum
PBS
phosphate-buffered saline
IHC
immunohistochemistry
SDS-PAGE
sodium dodecyl sulfate polyacrylamide gel electrophoresis
PVDF
polyvinylidene fluoride
qRT-PCR
quantitative real-time PCR
CCK-8
cell counting kit-8
FACS
fluorescence-activated cell sorting
KRAS
Kirsten rat sarcoma viral oncogene
MAPK
mitogen-activated protein kinase
ERK
extracellular regulated protein kinase
FGFR
fibroblast growth factor receptor
EGFR
epidermal growth factor receptor.
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These authors contributed equally.
© 2019 The Authors. Published by Elsevier B.V.