Clinical Studies
Decreasing prevalence of heterogeneous vancomycin-intermediate Staphylococcus aureus among blood isolates in Korean hospitals

https://doi.org/10.1016/j.diagmicrobio.2016.09.015Get rights and content

Highlights

  • The hVISA prevalence has decreased in Korea over the past decade.

  • This decrease in hVISA prevalence was observed regardless of vancomycin MIC.

  • A decreasing trend of hVISA prevalence was most obvious in ST5 MRSA.

Abstract

We investigated the prevalence of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) among methicillin-resistant S. aureus (MRSA) blood isolates collected from Korean hospitals. The hVISA prevalence in Korean hospitals has decreased during the past decade and the most significant decrease of hVISA prevalence was observed among the ST5 MRSA.

Section snippets

Background

Methicillin-resistant Staphylococcus aureus (MRSA) infections have imposed a high burden on healthcare resources as well as significant morbidity and mortality. A recent epidemiology of community-associated (CA) MRSA worldwide has added another serious concern (Joo et al., 2012). Furthermore, vancomycin-intermediate S. aureus (VISA) and heterogeneous VISA (hVISA) have been increasingly reported; however, the true prevalence of hVISA is unclear.

A nationwide surveillance of MRSA clinical isolates

Funding

This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012R1A1A2006672) and a grant (2013E4400400) from the Korea Centers for Disease Control and Prevention.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

Acknowledgements

Part of this research was presented at the Annual Meeting of the Korean Society of Infectious Diseases, Jeju, Korea, 2014.

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