Developmental Cell
Volume 28, Issue 1, 13 January 2014, Pages 1-2
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A RING to Rule Them All: RING1 as Silencer and Activator

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Polycomb proteins are known for silencing their target genes during development and cell differentiation. Reporting in Developmental Cell, Kondo et al. (2014) now show that Polycomb factors can also participate in gene activation by orchestrating the 3D chromatin structure changes involved in transcriptional activation of their target genes.

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