Developmental Cell
Volume 22, Issue 6, 12 June 2012, Pages 1163-1175
ArticleSpatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway
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Graphical Abstract
Highlights
► mVam2 mediates endocytic transport from late endosomes to lysosomes ► mVam2 is essential for assembly of large apical vacuoles in visceral endoderm ► Loss of mVam2 results in hyperactivation of BMP signaling ► The mVam2-dependent BMP attenuation contributes to patterning in gastrulation
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These authors contributed equally to this work
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Present address: Advanced Scientific Research Leaders Development Unit, Gunma University, 3-39-22, Showa, Maebashi, Gunma 371-8511, Japan
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