Current Biology
Volume 29, Issue 13, 8 July 2019, Pages R637-R639
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Cell Polarity: Getting the PARty Started

https://doi.org/10.1016/j.cub.2019.05.032Get rights and content
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Summary

Polarity establishment is a key developmental process, but what determines its timing is poorly understood. New research in Caenorhabditis elegans demonstrates that the PAR polarity system extensively reconfigures before becoming competent to polarize. By inhibiting membrane localization of anterior PAR proteins, AIR-1 (aurora A) and PLK-1 (polo kinase) prevent premature polarization.

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