Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database
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Graphical abstract
Abbreviations
A
acetaldehyde
AC
acetone
C
crotonaldehyde
CGPD
chemical-gene-phenotype-disease
COPD
chronic obstructive pulmonary disease
Cr
chromium
CTD
Comparative Toxicogenomics Database
F
formaldehyde
FR
free radicals
M
marker/mechanism relationship
MIE
molecular initiating event
MOA
mode-of-action
Mn
manganese
N
nicotine
NAFFCAPP
nicotine, acetaldehyde, formaldehyde, free radicals, crotonaldehyde, acetone, pyruvaldehyde, and particulate matter chemical mixture
NAFP
nicotine, acetaldehyde, formaldehyde, particulate matter chemical mixture
nAChR
nicotinic acetylcholine receptor
Ni
nickel
P
pyruvaldehyde
Pb
lead
PM
particulate matter
ROS
reactive oxygen species
Zn
zinc
Keywords
E-cigarettes
Vaping
Juul
Respiratory disease
Database
Environmental exposure
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© 2021 The Author(s). Published by Elsevier B.V.