Cell Reports Methods
Volume 1, Issue 4, 23 August 2021, 100052
ArticleRapid manipulation of mitochondrial morphology in a living cell with iCMM
Under a Creative Commons license
open access
Motivation
Mitochondria exhibit a variety of morphologies depending on the physiopathological condition of the cell, but the significance of changes in mitochondrial morphology remains almost unresolved. Although a method to induce mitochondrial morphological changes by altering the expression of proteins involved in mitochondrial dynamics has been established, this method requires several hours or more to induce mitochondrial morphological changes. Accordingly, a method to induce mitochondrial morphological changes at any given point in time on a minute timescale is needed.
Graphical abstract
Keywords
mitochondria
mitochondrial morphology
synthetic biocomputing device
synthetic biology
Boolean logic gate
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