Cell Metabolism
Volume 13, Issue 4, 6 April 2011, Pages 358-360
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A CRTCal Link between Energy and Life Span

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Cutting down calories prolongs life, but how this works remains largely unknown. A recent study in Nature (Mair et al., 2011) shows that life span extension triggered by the energy-sensing protein kinase AMPK is mediated by an evolutionarily conserved transcriptional circuit involving CRTC-1 and CREB.

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