Targeting human CD2 by the monoclonal antibody CB.219 reduces intestinal inflammation in a humanized transfer colitis model
Under a Creative Commons license
open access
Abbreviations
CCL
CC chemokine ligand
CXCL
CXC-motif ligand
FoxP3
forkhead box protein 3
hpf
high power field
huCD2tg
mice expressing human CD2
IBD
inflammatory bowel diseases
IFNγ
interferon γ
Ig
immunoglobulin
IL
interleukin
LPL
lamina propria lymphocytes
PBS
phosphate-buffered saline
Rag1-ko
recombination activating gene 1-deficient
TGFβ
transforming growth factor β
TNFα
tumor necrosis factor α
Treg
regulatory T cells
Keywords
Human CD2
IBD mouse model
Transfer colitis
Monoclonal antibody CB.219
Reduced intestinal inflammation
Cited by (0)
- 1
Present address: Immatics Biotechnologies GmbH, Paul-Ehrlich-Straße 15, Tübingen D-72076, Germany.
- 2
Present address: Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA.
- 3
Present address: Pathotres Joint Practice for Pathology, Teltowkanalstraße 2, Berlin D-12247, Germany.
Copyright © 2015 The Authors. Published by Elsevier Inc.