EFFECT OF ELECTROHYDRAULIC FOCUSED- SHOCK WAVE THERAPY ACCOMPANIED BY HDL- LOADED PESDA MICROBUBBLES ADMINISTRATION ON ARTERIAL BIOMECHANICAL PARAMETERS IN AN ANIMAL MODEL OF ADVANCED ATHEROSCLEROSIS
Section snippets
Background
It is known that high-fat diet, induce hypercholesterolemia, deterioration of arterial wall, both morphologically and mechanically. Mechanical changes include thickening of arterial wall, alteration of arterial elasticity, contraction of smooth muscle, increase in sensitivity to pharmacological stimulation and increase in arterial viscoelasticity, i.e., arteriosclerosis. The present study aimed to investigate the effect of focused- shock wave therapy accompanied by HDL- loaded microbubbles
Methods and Results
In this experimental study, the rabbits’ carotid arteries were injured by primary intravascular radiofrequency (F= 23.7 MHz, P= 10 W) thermal balloon angioplasty, followed by a 1.5% cholesterol- rich diet for eight weeks. Histology results showed severe stenosis (>70%) and neovascularization formation in all of the rabbits’ arteries. Then, the lesion region treated using pulsed- high intensity focused- shock wave (Frequency= 0.1 Hz, Volt= 15 Kv, Impulses= 100) accompanied by intravenous HDL-
Conclusion
Enhanced inertial cavitation effect of collapsed microbubbles within intraplaque neovessels, induced by pulsed focused shock wave accompanied by reverse cholesterol transport effect of HDL can cause to improvement of arterial mechanical parameters and finally, significantly plaque regression.