Clinical ResearchMyocardial Dimensions in Children With Hypertrophic Cardiomyopathy: A Comparison Between Echocardiography and Cardiac Magnetic Resonance Imaging
Section snippets
Methods
This was a single-centre prospective study. After approval by the institutional research ethics board all consecutive children and adolescents with genetically confirmed or suspected sarcomeric HCM referred for a routine clinical CMR studies were invited to participate. After informed written consent routine CMR imaging was performed. Exclusion criteria included inability to cooperate with the CMR acquisition or arrhythmias interfering with image acquisition. All patients received an
Results
Nineteen children and adolescents with HCM on previous TTE examination participated in the study, with a median age of 12.7 years (range, 8.4-18.4 years). No studies had to be excluded because of insufficient quality. Fifteen subjects (79%) were male. CMR-based wall measurements for all segments were successfully performed in all 19 subjects. In contrast, TTE measurements of each wall segment were only possible in 14 patients (74%). Reasons for failure of TTE to measure dimensions included
Discussion
Accurate assessment of the entire LV myocardium is important in the diagnosis, risk stratification, and follow-up of individuals with HCM10, 11, 12, 13 Echocardiography is the first-line investigation in assessing and following a child, adolescent, or adult with HCM because of its ease of use, relatively low cost, and ready availability, and confers important prognostic information.8, 14, 15 However, limited acoustic windows can lead to an inability to accurately quantify maximum wall
Conclusions
Echocardiography incompletely assesses circumferential myocardial thickness in a proportion of pediatric patients with HCM and underestimates maximum thickness compared with CMR. Our results suggest that CMR should be the diagnostic procedure of choice for children with suspected HCM.
Disclosures
The authors have no conflicts of interest to disclose.
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