Chest
Sleep: Original ResearchAllergic Rhinitis and OSA in Children Residing at a High Altitude
Section snippets
Design and Study Population
This observational cross-sectional study was performed in children consecutively recruited from the Sleep Laboratory of the Fundación Neumológica Colombiana between July 2018 and January 2019. The Fundación Neumológica Colombiana is a university-affiliated institution that serves as the reference center in respiratory medicine for the city of Bogotá, which is located at high altitude (2,640 m.a.s.l.). The study was approved by the institutional review board (Comite de Etica en Investigacion de
Results
Ninety-nine of the 100 patients recruited were included in the study (Fig 1). The remaining patient was excluded due to incomplete data. In the study group, 45.5% (n = 45) were female; subjects had an average age of 7.9 years, with 85.9% (n = 85) of patients born in the city of Bogotá and 94.9% (n = 94) living in an urban area. The patients resided in Bogotá (74%) or in nearby cities of the Altiplano Cundiboyacense (26%) (2640 m.a.s.l.) (Table 1). After a nutritional assessment, 10.1% (n = 10)
Discussion
The current study evaluated habitually snoring children with AR who reside at a high altitude and found that 53% of these symptomatic children had PSG-confirmed OSA. More importantly, an independent association between the severity of AR and the corresponding severity of OSA emerged. To the best of our knowledge, this study is the first that shows such a relation in children living at high altitudes. The positive correlation between the severity of AR (assessed by using the ESPRINT-15 and ARIA
Conclusions
We report a strong and significant and independent association between the severity of AR and the severity of OSA in children living at a high altitude. Further studies are needed to explore potential mechanisms underlying these findings.
Acknowledgments
Author contributions: L. F. G.-C. takes responsibility for the content of the article, including the data and analyses. L. F. G.-C., K. P. S., and J. L. C.-G. had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. M. I. E., M. S., N. G., D. G., and E. D.-M. contributed substantially to the study design, data analysis and interpretation, and the writing of the manuscript.
Financial/nonfinancial disclosures: None
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2022, Jornal de PediatriaCitation Excerpt :SDB is an important component of the morbidity associated with AR, and it is currently accepted that AR increases the risk of OSA.32,33 Although AR severity was found to have a significant and independent association with the severity of OSA in children,34 it was not confirmed in other PSG-diagnosed studies, despite the high prevalence of AR in patients with SDB.35-38 The Apnea-hypopnea index (AHI) during rapid eye movement (REM) sleep in children with moderate-severe OSA was significantly increased in subjects with rhinitis and OSA compared with those with OSA alone.35
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2021, International Journal of Pediatric OtorhinolaryngologyCitation Excerpt :Adenotonsillar hypertrophy is the main cause of pediatric OSA, and it can increase frequency of respiratory diseases in untreated childhood OSAS [3]. When accompanied by allergic rhinitis, bronchial asthma, and other airway inflammatory diseases, the decrease of pulmonary function is more obvious [4,5]. Abnormal lung function can objectively reflect airway hyper-responsiveness, which is associated with an increased risk for adverse airway events in children undergoing surgery [6].
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FUNDING/SUPPORT: This study was funded by Colciencias, Colombia [grant 335977757115; Colciencias call for funding: 777-2017].