Original article—alimentary tractClinical Course in Crohn’s Disease: Results of a Norwegian Population-Based Ten-Year Follow-Up Study
Section snippets
Material and Methods
From January 1, 1990 to December 31, 1993 all newly diagnosed patients with IBD or possible IBD were prospectively recorded in 4 geographically well-defined areas in South-Eastern Norway (Inflammatory Bowel South-Eastern Norway [IBSEN] study).
On January 1, 1992 the total study population was 966,427. All general practitioners in these areas (1236) were invited to participate in the study, and at each of the 15 participating hospitals, a senior gastroenterologist was made responsible for the
Follow-up Cohort
A complete 10-year follow-up was achieved in 197 of 237 patients (83.1%). The median follow-up time for these patients was 124 months (range, 108–144 months). Eighteen patients (7.6%) had died (median follow-up, 28 months; range, 0–83 months), and 22 patients (9.3%) were lost to follow-up (median follow-up, 53 months; range, 0–100 months). Of the patients lost to follow-up, 9 were not willing to participate further in the study, 7 had moved out of the area, 4 were untraceable, and 2 had other
Discussion
This 10-year follow-up study of newly diagnosed CD patients demonstrated the clinical phenotype, course of disease, and results of treatment in a population-based cohort. In addition, we have described potential risk factors for subsequent complications on the basis of clinical and epidemiologic variables at the time of the initial diagnosis.
This is one of few prospective population-based studies in this field,4, 16 and it has other methodologic advantages. First, the patients were uniformly
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The following members of the Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of gastroenterologists are thanked for participating in this study: Magne Henriksen, Østfold Hospital, Moss; Erling Aadland and Tomm Bernklev Aker, University Hospital, Oslo; Stein Dahler, Notodden Hospital, Øystein Kjellevold, Blefjell Hospital, and Finn Strøm, Lovisenberg Diakonale Hospital, Oslo. For help with statistical analysis we thank Milada Småstuen, Department of Biological Statistics, Rikshospitalet University Hospital.