Cell Reports
Volume 1, Issue 5, 31 May 2012, Pages 408-416
ReportThe Functional Antagonism between Eg5 and Dynein in Spindle Bipolarization Is Not Compatible with a Simple Push-Pull Model
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Graphical Abstract
Highlights
► Fixed-cell microscopy images overestimate the frequency of defective mitotic spindles ► Live-cell-imaging-based conclusions often contradict results from fixed samples ► Antagonizing mitotic spindle motor activities of dynein and Eg5 are not titratable ► Spindle dynein-Eg5 antagonism is incompatible with a simple push-pull mechanism
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Present address: Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Warren Alpert Building 536, Boston, MA 02115, USA
Copyright © 2012 The Authors. Published by Elsevier Inc.