Cell
ArticleModeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant
Graphical Abstract
Highlights
► Selected East Asian EDAR allele, 370A, emerged in central China ∼30,000 years ago ► Hair, sweat, and mammary glands are altered in a 370A knockin mouse model ► The novel effect of 370A on mouse sweat gland density is recapitulated in humans
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These authors contributed equally to this work
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These authors contributed equally to this work and are cosenior authors
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Present address: Max Planck-CAS Paul Gerson Unna Research Group on Dermatogenomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
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Present address: St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA
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Present address: Department of Systems Biology Harvard Medical School, Boston, MA 02115, USA
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Present address: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
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Present address: Department of Stem Cell Biology and Regenerative Medicine, Broad-CIRM Center, Keck School Of Medicine, University of Southern California, CA 90089, USA