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Homeostasis of peripheral immune effectors

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Abstract

In this paper, we use both mathematical modeling and simulation to explore homeostasis of peripheral immune system effector cells, particularly alveolar macrophages. Our interest is in the distributed control mechanisms that allow such a population to maintain itself. We introduce a multi-purpose simulator designed to study individual cell responses to local molecular signals and their effects on population dynamics. We use the simulator to develop a model of growth factor regulation of macrophage proliferation and survival. We examine the effects of this form of regulation in the context of two competing hypotheses regarding the source of new alveolar macrophages. In one model, local cells divide to replenish the population; in the other, only cells migrating from circulation divide. We find that either scenario is plausible, although the influx-driven system is inherently more stable. The proliferation-driven system requires lower cell death and efflux rates than the influx-driven system.

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Authors and Affiliations

  1. Department of Computer Science, 1 University of New Mexico, Albuquerque, NM, 87131-0001, USA

    Christina Warrender & Stephanie Forrest

  2. Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe, NM, 87501, USA

    Stephanie Forrest

  3. Department of Computer Science and Applied Mathematics, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Lee Segel

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  1. Christina Warrender
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  2. Stephanie Forrest
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  3. Lee Segel
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Correspondence to Christina Warrender.

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Warrender, C., Forrest, S. & Segel, L. Homeostasis of peripheral immune effectors. Bull. Math. Biol. 66, 1493–1514 (2004). https://doi.org/10.1016/j.bulm.2004.02.003

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  • DOI: https://doi.org/10.1016/j.bulm.2004.02.003

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