Elsevier

Brain Research

Volume 1002, Issues 1–2, 26 March 2004, Pages 151-157
Brain Research

Short communication
Social approach–avoidance behavior of inbred mouse strains towards DBA/2 mice

https://doi.org/10.1016/j.brainres.2003.12.013Get rights and content

Abstract

Little is known about the genetics of social approach–avoidance behaviors. We measured social approach–avoidance of prepubescent female C57BL/6J, DBA/2J, FVB/NJ, AKR/J, A/J, and BALB/cJ mice towards prepubescent DBA/2J female mice. C57BL/6J mice showed the greatest predominance of approach, while BALB/cJ mice showed the greatest predominance of avoidance. Thus, this phenotype is affected by spontaneous genetic variation in mice and can be measured in an assay useful for future neurogenetic studies.

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Acknowledgements

Edward S. Brodkin is a recipient of a Burroughs Wellcome Fund Career Award in the Biomedical Sciences. This investigation was supported by National Institutes of Health, National Research Service Award 1 F32 MH12203-01 from the National Institute of Mental Health and R37 HD20275-17. We thank Susan Dodge, Sarah A. Goforth, and Angela H. Keene for their technical assistance, and we thank Irwin Lucki for his comments on the manuscript.

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