Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Archival ReportCognitive Modeling Informs Interpretation of Go/No-Go Task-Related Neural Activations and Their Links to Externalizing Psychopathology
Section snippets
Participants
An initial sample of 147 participants, 18 to 21 years of age, was recruited from the Michigan Longitudinal Study (MLS) to participate in a neuroimaging study. The MLS is an ongoing prospective study that follows a community sample of families with a history of alcohol use disorder and low-risk families from the same neighborhoods (36,37). Participants were excluded from participating in the larger MLS if they displayed signs of fetal alcohol syndrome and were excluded from the neuroimaging
DDM Parameter Estimates
Plots comparing empirical RT and accuracy data to predictions of the DDM suggested that the model generally described behavioral data well (Supplement). Notably, most participants’ z values were above 0.50 (Table 1), indicating that they were biased toward the decision to respond, as would be expected for a task with a greater proportion of go than no-go stimuli.
Table 2 displays Pearson correlation (r) values and credible intervals for relationships between all DDM parameters and traditional
Discussion
We used the DDM, a well-validated computational model (30,31), to test the common assumption that individual differences in go/no-go task-related neural activations index the integrity of neurocognitive mechanisms that underlie individual and clinical differences in inhibitory performance.
FI-related activations in the ACC, IFG, and insula, regions associated with error processing (22,24), were consistently positively related to individuals’ drift rate (v.avg) across whole-brain and ROI-based
Acknowledgments and Disclosures
This project was supported by National Institute on Alcohol Abuse and Alcoholism (NIAAA) Grant Nos. R01 AA07065 (to RZ) and R01 AA025790 (to MH). AW was supported by NIAAA Grant No. T32 AA007477 (to Dr. Frederic Blow, principal investigator).
This article was published as a preprint on bioRxiv: doi: https://doi.org/10.1101/614420.
The authors report no biomedical financial interests or potential conflicts of interest.
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