Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways
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Declaration of Competing Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Acknowledgments
This work was supported by grants from the Natural Science Foundation of China (NSFC) (Nos. 81773866, 81771377 and U1705285), Fundamental Research Funds for the Central Universities (No. 20720190079) and Natural Science Foundation of Fujian Province of China (No. 2019J007).
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A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
2021, PhytochemistryCitation Excerpt :MTT assays showed that daphnegiranol D1 and D2 had a selectively cytotoxic effect against Hep3B cells with the IC50 value of 4.87 and 3.35 μM, respectively, which showed more potent than the positive control sorafenib (IC50 = 6.59 μM). Additionally, 22 natural prenylated flavonoids (167–196) (Fig. 3) (Table 1) were evaluated their cytotoxicity against several human cell lines in vitro by the MTT method (Li et al., 2014b; Liu et al., 2018; Long et al., 2021; Fu et al., 2011; Ogungbe et al., 2011; Su et al., 2012; Yang et al., 2014a, b; Ye et al., 2021). The result indicated that prenylated isoflavones (174–181) exhibited the significant anti-proliferative effects against five human cancer cell lines such as HL-60, SMMC-7721, A-549, MCF-7 and SW480 with IC50 values ranging from 0.16 to 12.68 μM.
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2023, Archives of Pharmacal ResearchExtract of Ficus septica modulates apoptosis and migration in human oral squamous cell carcinoma cells
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This authors contributed equally to this work.