Synthesis and biological evaluation of a series of fatty acid amides from Echinacea

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Abstract

Alkylamides are lipophilic constituents of Echinacea and possess numerous biological activities. Although significant effort has been focused on the study of crude Echinacea extracts, very little is known regarding the activities of the individual constituents that make up these herbal treatments. Herein we explore the SAR of simple alkylamides found in Echinacea extracts with respect to their ability to decrease the production of the pro-inflammatory mediator TNF-α. Our results have revealed the key structural requirements for activity and provide lead compounds for further investigation of these poorly understood molecules.

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Acknowledgments

This work was partially funded by NC State’s Office of Research, Innovation, and Economic Development, in partnership with the Kenan Institute for Engineering, Technology and Science and the Center for Comparative Medicine and Translational Research. JGP gratefully acknowledges North Carolina State University for generous start-up support. Mass spectra were obtained at the Mass Spectrometry Laboratory at NC State University.

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