Novel imidazo[2,1-b][1,3,4]thiadiazole carrying rhodanine-3-acetic acid as potential antitubercular agents

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Abstract

The increase in the prevalence of multi drug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis case demonstrates the urgent need of discovering new promising compounds with antimycobacterial activity. As part of our research program and with a aim of identifying new antitubercular drug candidates, a new class of 2-(trifluoromethyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazole derivatives has been synthesized by both conventional as well as microwave assisted method and evaluated for their in vitro antitubercular activity against M. tuberculosis H37Rv. Moreover, various drug-likeness properties of new compounds were predicted. Seven compounds from the series exhibited good activity with MIC in range 3.12–1.56 μg/ml. The present study suggests that compounds 6b, 6c, 6d, 6e and 6f may serve as promising lead scaffolds for further generation of new anti-TB agents.

Graphical abstract

Microwave-assisted synthesis and investigation of antitubercular profile of new 2-(trifluoromethyl)-6-arylimidazo[2,1-b][1,3,4]-thiadiazole derivatives are described.

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Acknowledgments

Authors are grateful to Dr. A. D. Taranalli, Principal, for providing necessary facilities. We wish to express our sincere gratitude to Dr. F. V. Manvi, Dean Faculty of pharmacy and Dr. C. K. Kokate, Vice-Chancellor for their motivation. Authors are also grateful to NMR Research center, IISC, Bangalore, India, for providing the spectral data.

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