Pyrazolopyridine inhibitors of B-RafV600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing
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Acknowledgements
The authors thank Jaroslaw Mazurek from Avantium for determination of the crystal structure of 1 and Antonio DiPasquale from The University of California, Berkeley for determination of the crystal structure of 6. The authors also thank Kevin Hunt, Yvan LeHuerou, Li Ren, Stephen Schlachter, and Tony Tang for helpful discussions and support.
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