Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents
Graphical abstract
Synthesis of a new series of quinoline-3-carbohydrazones is presented together with the pharmacological profiles. Compounds 13e, 13i, 13k, 14a, 14c, and 14i emerged as the lead molecules with MIC ranging 0.625–5 μg/mL and did not show toxicity on Vero cells up to 62.5 μg/mL which are in comparable with the present first line anti tuberculosis drugs.
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Acknowledgment
Authors are thankful to Dr. Ganesh Sambhasivam, CEO, Anthem biosciences, Bangalore, India, for his invaluable support and allocation of resources for this work. They are also grateful to the Head, Chemistry Department, NITK for providing necessary laboratory facilities for the research work and valuable support.
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