The discovery of equipotent PPARα/γ dual activators

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Abstract

We report the design and synthesis of equipotent PPARα/γ dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.

Graphical abstract

We report the design and synthesis of equipotent PPARα/γ dual agonists starting from the selective PPARα agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.

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Acknowledgments

We thank Dr. Andrew Brewster (GlaxoSmithKline) for proofreading of the manuscript.

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