Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP

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Abstract

The synthesis of mono- and bisphosphorothioate analogues of 3′,5′-cyclic diguanylic acid (cdiGMP) via the modified H-phosphonate chemistry is reported. The immunostimulatory properties of these analogues were compared with those of cdiGMP.

Graphical abstract

The phosphorothioate analogues of cdiGMP were synthesized and their immunostimulatory properties were compared.

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Acknowledgments

This work is supported by Research Corporation, Canada Foundation for Innovation, Natural Sciences and Engineering Research Council of Canada, and National Research Council Canada (A-base). The authors thank Tim Jones and Razvan Simionescu for mass spectrometric and NMR analysis, respectively, and Mr. Greg Harris for Luminex assay.

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