Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP
Graphical abstract
The phosphorothioate analogues of cdiGMP were synthesized and their immunostimulatory properties were compared.
Section snippets
Acknowledgments
This work is supported by Research Corporation, Canada Foundation for Innovation, Natural Sciences and Engineering Research Council of Canada, and National Research Council Canada (A-base). The authors thank Tim Jones and Razvan Simionescu for mass spectrometric and NMR analysis, respectively, and Mr. Greg Harris for Luminex assay.
References and notes (15)
Curr. Opin. Microbiol.
(2004)- et al.
Vaccine
(2007) - et al.
Tetrahedron
(2006) - et al.
Tetrahedron Lett.
(2004) - et al.
Mol. Microbiol.
(2005) - et al.
Mol. Microbiol.
(2004) - et al.
Clin. Vaccine Immunol.
(2007)
Cited by (51)
Recent Advances in the Direct Synthesis of Sulfur-Containing Organophosphorus Compounds via Radical Processes
2023, Advanced Synthesis and CatalysisHighly Chemoselective Transformation of Secondary Propargylic Alcohols with (EtO)<inf>2</inf>P(O)SH
2022, Asian Journal of Organic ChemistryNanodelivery of STING agonists against cancer and infectious diseases
2022, Molecular Aspects of MedicineChemical evolution of cyclic dinucleotides: Perspective of the analogs and their preparation
2021, TetrahedronCitation Excerpt :It is not easy to purify and distinguish the absolute diastereoisomer. Baran et al. [138] developed a fundamental method for the stereocontrolled synthesis of the diastereoselective phosphorus-sulfur incorporation. As shown in Scheme 16, the authors developed the pre-synthesized chiral P(V)-based reagents 181a and 181b.