Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2
Graphical abstract
The first selective CRTH2 antagonist radioligand exhibits a pKd of 9.0 and a specific radioactivity of 52 Ci/mmol.
Section snippets
Acknowledgment
This work was supported by the Danish Research Council.
References and notes (22)
- et al.
Trends Mol. Med.
(2006) - et al.
Pharmacol. Ther.
(2004) - et al.
Blood
(2001) - et al.
Bioorg. Med. Chem. Lett.
(2006) - et al.
Bioorg. Med. Chem. Lett.
(2007) - et al.
Eur. J. Pharmacol.
(2005) - et al.
J. Exp. Med.
(2007) - et al.
J. Exp. Med.
(2001) - et al.
Hum. Mol. Genet.
(2004) - et al.
Int. Immunol.
(2004)
J. Immunol.
(2005)
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