Microwave prompted multigram synthesis, structural determination, and photo-antiproliferative activity of fluorinated 4-hydroxyquinolinones
Graphical abstract
A simple facile one-step microwave enhanced multigram synthesis of such fluorinated quinolones in reasonable purity has been developed in excellent yield (85–94%) in 3–5 min and evaluated for photo-antiproliferative, antimicrobial, and antituberculosis activities.
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Acknowledgments
The authors wish to express their appreciation to Dr. André Loupy, Laboratoire des Réactions Sélectives Sur Supports, Université Paris-Sud, Orsay cedex, France, for his generous support and valuable suggestions. We are also thankful to Indian Oil Corporation, R&D Center, for spectral and financial supports and Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) for antimycobacterial data.
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