Effects of α-substitutions on structure and biological activity of anticancer chalcones

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Abstract

Chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerisation. We describe here the effects of different α-substitutions, in particular α-fluorination, on the structure and biological activity of a series of chalcones.

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Acknowledgments

The support of our work by the EPSRC (Research Grant GR/S25456/01: 500 MHz NMR spectrometer; the EPSRC Chemical Database Service at Daresbury,26 the EPSRC National Mass Spectrometry Centre at Swansea University for High-Resolution Mass Spectrometry), BBSRC (Research Grants B18009 and B18017), Cardiff University (Senior Research Fellowship to N.J.L., and studentship to R.P.P.) and the Moffitt Cancer Center is gratefully acknowledged.

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