Epibatidine isomers and analogues: Structure–activity relationships

doi:10.1016/j.bmcl.2006.08.049

Bioorganic & Medicinal Chemistry Letters

Volume 16, Issue 21, 1 November 2006, Pages 5493-5497

https://doi.org/10.1016/j.bmcl.2006.08.049 Get rights and content

Abstract

Binding affinities for a range of epibatidine isomers and analogues at the α4β2 and α3β4 nAChR subtypes are reported; compounds having similar N–N distances to epibatidine show similar, high potencies.

Graphical abstract

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Epibatidine isomers and analogues: Structure–activity relationships

Abstract

Graphical abstract

J. Am. Chem. Soc.

Bioorg. Med. Chem. Lett.

EMBO J.

J. Chem. Soc., Perkin Trans. 1

J. Chem. Soc., Perkin Trans. 1

J. Org. Chem.

Bioorg. Med. Chem.

J. Am. Chem. Soc.

J. Am. Chem. Soc.

J. Med. Chem.

Bioorg. Med. Chem. Lett.

J. Med. Chem.

Curr. Top. Med. Chem.