Antiophidic potential of chlorogenic acid and rosmarinic acid against Bothrops leucurus snake venom
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Graphical Abstract
Abbreviations
AUC0–3 h
areas under the time-course curves at 3 h
Av
antivenom serum
ALT
alanine transaminase
APTT
activated partial thromboplastin time
Asp49
phospholipase with an aspartic acid at position 49
AST
aspartate transaminase
BlV
Bothrops leucurus venom
CA
chlorogenic acid
CA 10
chlorogenic acid at 10 mg/kg
CA 15
chlorogenic acid at 15 mg/kg
CA 20
chlorogenic acid at 20 mg/kg
CGEN
Brazilian Genetic Heritage Management Council
CK
creatine kinase
CONCEA
National Council for the Control of Animal Experimentation of Brazil
DAMPs
damage-associated molecular patterns
Dex
dexamethasone at 2 mg/kg
ELISA
Enzyme-Linked Immunosorbent Assay
His
histidine
IL-1β
interleukin 1 beta
IL-6
interleukin-6
i.m.
intramuscular
i.p.
intraperitoneal
i.pl.
intraplantar
LAAO
L-amino acid oxidase
LDH
lactate dehydrogenase
LPS
lipopolysaccharide
Lys49
phospholipase with a lysine at position 49
MDA
malondialdehyde
MPO
myeloperoxidase
NF-kB
Nuclear Factor Kappa-Β
NTDs
Neglected Tropical Diseases
PDB
protein data bank
PBS
phosphate buffered saline
PLA2
phospholipase A2
PT
prothrombin time
RA
rosmarinic acid
RA 10
rosmarinic acid at 10 mg/kg
RA 15
rosmarinic acid at 15 mg/kg
RA 20
rosmarinic acid at 20 mg/kg
s.c.
subcutaneous
SEM
standard error of mean
SVMP
snake venom metalloprotease
SVMP P-III
snake venom metalloprotease type III
SVSP
snake venom serine protease
TBARS
thiobarbituric acid reactive substances
TNF-α
tumor necrosis factor alpha
UFRN
Federal University of Rio Grande do Norte
WHO
World Health Organization
α2M
alpha-2 macroglobulin
Keywords
Antiophidic activity
Phenolic compounds
Bothrops leucurus
Inhibition of toxins
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© 2022 Published by Elsevier Masson SAS.