Tongmai formula improves cardiac function via regulating mitochondrial quality control in the myocardium with ischemia/reperfusion injury
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Graphical abstract
Abbreviations
I/R
ischemia/reperfusion
TM
Tongmai formula
NRVMs
neonatal rat ventricular myocytes
H/R
hypoxia/reoxygenation
JC-1
5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide
ROS
reactive oxygen species
TMRM
tetramethylrhodamine methyl ester
Mfn2
mitofusin 2
Drp1
dynamin related protein 1
mPTP
mitochondrial permeability transition pore
EF%
ejection fraction percentage
FS%
fraction shortening percentage
Peak Vel
peak velocity
dP/dt
maximum rate of left ventricular systolic pressure rises
TCC
2,3,5-triphenyltetrazolium chloride
H&E
hematoxylin and eosin
CK
Creatine kinase
LDH
lactate dehydrogenase
SOD
superoxide dismutase
MDA
malondialdyhyde
cTnT
cardiac troponin T
GSH
glutathione
DCFH-DA
2′,7’-dichlorofluorescin diacetate
TMRM
Tetramethylrhodamine methyl ester
ΔΨm
mitochondrial membrane potential
CYCS
cytochrome c
AIF
apoptosis inducing factor
Keywords
Mitochondrial quality control
Tongmai formula
Myocardial ischemia/reperfusion
Mitochondrial morphosis
Mitochondrial dynamics
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© 2020 The Authors. Published by Elsevier Masson SAS.