WSZG inhibits BMSC-induced EMT and bone metastasis in breast cancer by regulating TGF-β1/Smads signaling
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open access
Graphical abstract
Abbreviations
WSZG
Wensheng Zhuanggu Formula
BMSCs
bone marrow-derived mesenchymal stem cells
EMT
epithelial-mesenchymal transition
TCM
traditional Chinese medicine
TGF-β1
transforming growth factor-β1
DMEM
Dulbecco’s modified Eagle’s medium
BMSC-CM
BMSC-conditioned medium
BLI
in vivo bioluminescent imaging
ELISA
enzyme linked immunosorbent assay
ZA
zoledronic acid
real-time PCR
real-time polymerase chain reaction
Ct
comparative threshold
MTT
3-(4,5)- dimethylthiazolyl)-3,5-diphenyltetrazolium bromide
H&E
hematoxylin and eosin
IHC
immunohistochemistry
OD
optical density
AIOD
average integral optical density
Keywords
Breast cancer
Bone
Metastasis
Wenshen Zhuanggu Formula
Bone marrow-derived mesenchymal stem cell
Epithelial-mesenchymal transition
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These authors contributed equally to this work.
© 2019 The Authors. Published by Elsevier Masson SAS.