Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy
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Graphical abstract
Biomimetic Manganese-Based Nanoplatform (GSMM) demonstrates superior performance in multimodal caner imaging, including PTI, PAI and MRI. In acidic tumor microenvironment, GSMM can be degraded into Mn2+, which catalyzes H2O2 into ·OH for CDT leading to activate cGAS-STING signaling, but also directly acts on STING inducing secretion of IFN I, pro-inflammatory cytokines and chemokines.
Keywords
Biomimetic
Manganese ions
The second near-infrared window
Cancer imaging
Immunotherapy
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These authors contributed equally to this work.
© 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.