Probing the molecular basis for signal transduction through the Zinc-Activated Channel (ZAC)
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Graphical abstract
Keywords
Cys-loop receptor (CLR)
Pentameric ligand-gated ion channel (pLGIC)
Zinc-Activated Channel (ZAC)
Agonist binding
Chimeric subunits
Leu9′ residue
Abbreviations
5-HT
5-hydroxytryptamine
5-HT3R
5-HT3 receptor
CLR
Cys-loop receptor
ECD
extracellular domain
GABA
γ-aminobutyric acid
GABAAR
GABAA receptor
GlyR
glycine receptor
nAChR
nicotinic acetylcholine receptor
TEVC
two-electrode voltage clamp
TMD
transmembrane domain
ICD
intracellular domain
ZAC
Zinc-Activated Channel
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N.M. and E.M. contributed equally to this work and are co-first-authors.
© 2021 The Author(s). Published by Elsevier Inc.