EditorialOxysterols and related sterols: Implications in pharmacology and pathophysiology
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Acknowledgments
The editors would like to thank A. Athias, O. Berdeaux, L. Bretillon, L. Iuliano, G. Lizard, J.-P. Pais and A Vejux for organizing the 2nd ENOR symposium. We also thank the ENOR, the INSERM, the Université de Bourgogne, the INRA, the Conseil Regional de Bourgogne, Agilent Technologies France, BD Biosciences, Bureau interprofessionnel des vins de bourgognes, the IFR santé STIC, Life Technologies, Odil sas, and Oncodesign for additional support.
Finally we would like to thank the organizers and
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Cited by (8)
7-Ketocholesterol and cholestane-triol increase expression of SMO and LXRα signaling pathways in a human breast cancer cell line
2019, Biochemistry and Biophysics ReportsCitation Excerpt :The most studied oxysterols, at least in terms of toxicity, are 25-hydroxycholesterol, 7β-hydroxycholesterol, and 7-ketocholesterol. The cytotoxic effects of these oxysterols have been demonstrated in several cell lines [16,22,35,37–42]. Here, as expected, 7-KC, triol, and diol reduced the number of cells.
Oxysterols selectively promote short-term apoptosis in tumor cell lines
2018, Biochemical and Biophysical Research CommunicationsCitation Excerpt :The most studied oxysterols, at least in terms of toxicity, are 25-hydroxycholesterol, 7β-hydroxycholesterol, and 7-ketocholesterol. The cytotoxic effects of these oxysterols have been demonstrated in several cell lines [15,21,30,32–37]. Here, we extended those observations by evaluating the effects of several other oxysterols on cell death and the cell cycle in tumorigenic and non-tumorigenic cell lines.
Extracellular vesicles: Lipids as key components of their biogenesis and functions
2018, Journal of Lipid ResearchCitation Excerpt :In yeast, Vps4 has been shown to interact with the oxysterol binding proteins, Osh6 and Osh7 (6). Oxysterols have specific pharmacological and physiological properties (7). Alix is recruited on the endosome membrane via a specific domain binding the endosomal lipid, bis(monoacylglycero)phosphate (BMP) (8), also inappropriately named LBPA for lyso(bis)phosphatidic acid.
One step synthesis of 6-oxo-cholestan-3β,5α-diol
2014, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Oxysterols, like steroid hormones, have specific physiological properties and deregulation of their metabolism is associated with several pathologies including cancer [1–6]. Some oxysterol metabolic pathways represent novel targets for the development of anticancer agents [2,5,7]. Working on cholesterol (1) metabolism and cancer, our team has recently established the molecular identification of the cholesterol-5,6-epoxide hydrolase (ChEH) [8].
Dose-Response Effects of 7-Dehydrocholesterol Reductase Inhibitors on Sterol Profiles and Vesicular Stomatitis Virus Replication
2022, ACS Pharmacology and Translational Science