Elsevier

Behavioural Brain Research

Volume 419, 15 February 2022, 113701
Behavioural Brain Research

Short communication
Neurobehavioral effects of chronic low-dose vanadium administration in young male rats

https://doi.org/10.1016/j.bbr.2021.113701Get rights and content

Highlights

  • Vanadium did not alter locomotor or exploratory behavior.

  • Vanadium exposure affected performance on the novel object recognition task.

  • Vanadium administration benefited the acquisition of the Morris Water maze.

Abstract

Exposure to the metal vanadium, in both animals and humans has been linked to various physiological consequences including respiratory and gastrointestinal conditions. Research on the neurobehavioral effects of vanadium exposure is limited. Hence, the purpose of the current study was to examine the effects of chronic low-dose vanadium administration (0.04 mg/week) on the behavior of young male rats. Four weeks following the administration of vanadium, rats were tested on the open field, object recognition, and Morris Water maze tasks. Vanadium did not affect exploration, locomotion, or anxiety-like behavior as measured by the open field task. Vanadium administration affected novel object recognition performance. Intriguingly, rats exposed to vanadium exhibited lower latency times on day 2 of the Morris Water maze. These findings suggest that vanadium’s behavioral effects are complex and warrant further investigation to better understand the potential benefits and consequences of its exposure.

Section snippets

Acknowledgements

The authors gratefully acknowledge research support by West Texas A&M University’s Killgore graduate student grant program (United States) awarded to Amanda Dyer.

References (27)

  • F. Han et al.

    The vanadium (IV) compound rescues septo-hippocampal cholinergic neurons from neurodegeneration in olfactory bulbectomized mice

    Neuroscience

    (2008)
  • J. Liu et al.

    Environmental toxicity and poor cognitive outcomes in children and adults

    J. Environ. Health

    (2014)
  • J. Seo et al.

    Lead-induced Impairments in the neural processes related to working memory function

    PloS One

    (2014)
  • Cited by (5)

    View full text