Review
Emerging Influence of the Intestinal Microbiota during Allogeneic Hematopoietic Cell Transplantation: Control the Gut and the Body Will Follow

https://doi.org/10.1016/j.bbmt.2015.02.016Get rights and content
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Highlights

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    Immune components and commensals are necessary in maintaining intestinal homeostasis.

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    Complications following allogeneic transplantation can affect the microbiota.

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    Diversity of the microbiota can lead to advantages in HCT-related outcomes.

Abstract

The intestinal microbiota has many critical roles in maintaining gastrointestinal epithelial and gastrointestinal systemic immune homeostasis. This review provides insight into how allogeneic hematopoietic cell transplantation (HCT) and its associated complications and supportive care therapies affect the microbiota. Additionally, the review discusses how preservation and restoration of the microbiota might be advantageous in decreasing HCT-related morbidity and mortality.

Key Words

Antimicrobial peptide
Bone marrow transplant
Bacteremia
Clostridium difficile
Dysbiosis
Enterocyte
Graft-versus-host disease
Gut microbiota
IL-22
Paneth cell
Regenerating islet-derived III alpha
T cell
Tolerance

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Financial disclosure: See Acknowledgments on page 1365.

Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.